Here’s a look at all 16 matchups and point spreads for the NFL Week 1 schedule

It’s here, finally. No more meaningless preseason games. No more talking about and previewing the season ad nauseam.

Week 1 of the NFL season kicks off Thursday night in Kansas City, where the defending Super Bowl champion Chiefs start their 2023-24 campaign not against the NFC champion Eagles, but with a prime-time game against the upstart Detroit Lions.

The Eagles, meanwhile, head up to Massachusetts to face the Patriots.

» READ MORE: The Inquirer's Eagles season preview: What's in store for the Birds in 2023

Though neither point spread is a full touchdown and extra point, the Chiefs (-6.5) and Eagles (-4) are among the larger favorites in a Week 1 slate that is full of intrigue.

Here’s a look at betting lines for all 16 NFL Week 1 games.

Odds are courtesy of BetMGM, current at the time of publishing, and subject to change.

(Home team listed first; all times Eastern)

The season opener on NBC is an interesting one, with Patrick Mahomes and Co. looking to start strong against a Lions team that is turning the corner.

Will the Cardinals finish with the worst record in the NFL in Jonathan Gannon’s first season? Being touchdown underdogs against Washington says a lot.

» READ MORE: An early look at some interesting Eagles prop bets ahead of the NFL regular season

Let the Bijan Robinson Rookie of the Year run commence in Atlanta.

Deshaun Watson vs. Joe Burrow in a divisional matchup in Cleveland. This game is easily the best of the 1 p.m. slate.

This is the biggest number of Week 1. C.J. Stroud gets his first NFL start, and new Texans coach DeMeco Ryans gets his first NFL game as a head coach. Waiting for them is Lamar Jackson and Co.

» READ MORE: Could Jets wide receiver Garrett Wilson be worth a flier to lead NFL in receiving yards?

Doug Pederson’s Jaguars made some noise last season. Will they get off to a good start Sunday on the road?

The 49ers are right behind the Eagles on the NFC odds board, but they start the season as a short road favorite in Pittsburgh.

The Tom Brady era is over in Tampa, while Minnesota has playoff expectations once again.

Derek Carr is the new quarterback in town in New Orleans. The Titans, meanwhile, added DeAndre Hopkins to a team that went 7-10 last season.

» READ MORE: Eagles QB Jalen Hurts presents best value to win NFL MVP during 2023 NFL season

Speaking of era ending. The Aaron Rodgers era is over in Green Bay, and the Jordan Love era begins with a divisional, coin-flip road game in Chicago.

Star wide receiver Cooper Kupp will see a specialist for his hamstring injury. Without him, the Rams’ offense is much weaker.

A preview of an AFC playoff matchup? Both were wild-card teams last season.

Can Sean Payton help the Broncos and Russell Wilson turn things around?

The NFC champion Eagles will likely be favored in their first five contests, starting Sunday at New England.

» READ MORE: How to bet A.J. Brown’s receiving props after a dominant first season with the Eagles

NBC’s Sunday Night Football schedule kicks off with a rivalry NFC East matchup at MetLife Stadium. Which team will be hunting the Eagles for the top spot in the division? We’ll have a good answer by midnight.

Rodgers gets his first start with the Jets in a big one: With division rival Buffalo and Josh Allen coming to town. The Bills have Super Bowl aspirations, and the Jets want to show they’re going to be in the hunt for a playoff spot.